![]() Second focus of the lab is related to some recent findings of Genome-Wide Association Studies (GWAS). genome-wide search approach which relies on bioinformatics analysis and deep sequencing technology. candidate gene approach which involves stem cell culture and differentiation 2. The lab is now working on finding more examples of “trans-splicing.” For that, we are taking two approaches: 1. ![]() Precursor mRNAs from separate genes can be joined by “trans-splicing” and the chimeric RNA can then be translated into fusion protein. Our recent findings have turned this dogma “on its head.” We have shown that the fusion products can be present in normal cells and they can be made through a mechanism that doesn’t require DNA translocation. Since its discovery, gene fusions have been viewed as unique features of cancer and they all result from chromosomal translocation. The common thread linking all of the research projects over the years has been the study of mechanisms underlying hematopoietic lineage commitment, in particular the divergence of the erythroid and megakaryocytic lineages from a common progenitor cell. The second consists of the mechanisms underlying erythropoietin resistance in certain types of anemias. The first consists of the regulatory pathways involved in programming the early stages of megakaryocytic differentiation. Our lab has maintained two major, extramurally-funded areas of investigation in the field of hematology. Adam Goldfarb, M.D., Laboratory Interests Mechanisms of Differentiation in Hematologic Cell Lineages.The Medical Automation Research Center focuses on developing new automation technologies that improve the efficiency, safety and relevance of medical care. Our current program project grant is focused on investigating how the kidney regulates sodium transport and blood pressure through shared and independent molecular, cellular, and physiological pathways. Jose (Pediatrics, Georgetown University, Washington, D.C.) and over 50 M.D.s, Ph.D.s, students and technologists that are studying the interaction between two regulatory pathways (dopamine and the renin angiotensin system) with key roles in kidney function and blood pressure regulation. Carey (Endocrinology), and co-investigator Dr. Our research team consists of the Principal Investigator, Dr. High Blood Pressure (hypertension) and Blood Pressure Sensitivity to Salt Robin Felder, Ph.D., Laboratory Interests I. ![]() Our studies are intended to help develop vaccines against tumors. We are particularly interested in how CD4+ “helper” T cells and dendritic cells (which are responsible for activating T lymphocytes) contribute to the immunological control of tumors. Under the umbrella of the Human Immune Therapy Center, our laboratory seeks to gain a greater understanding of the interactions between the immune system and tumors. Timothy Bullock, Ph.D., Laboratory Interests Tumor Immunotherapy.UVA Child Development & Rehabilitation Center.Translational Health Research Institute of Virginia.Institute of Law, Psychiatry & Public Policy.Child Health Research Center (Pediatrics).Thaler Center for AIDS & Human Retrovirus Research Center for Immunity, Inflammation & Regenerative Medicine.Center for Behavioral Health & Technology.Molecular Physiology & Biological Physics. ![]()
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